• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
    公开号:SU955857A3
    申请号:SU782632596
    申请日:1978-07-05
    公开日:1982-08-30
    发明作者:Энджел Ондетти Мигель；Вэйн Кашман Дэвид
    申请人:Е.Р.Сквибб Энд Санз, Инк (Фирма)；
    IPC主号:
    专利说明:

    (54) METHOD FOR OBTAINING MERCAPTOACYLAMIC ACIDS The invention relates to a process for the preparation of novel mercapto acylamino acid derivatives form. | Вг Ri Е jd О - $ - dHz-dH-И (-kn - with n- | y, where Ryj is hydrogen, C. | -Cj-alkyl, substituted by phenyl, hydroxyphenyl, indole or guanidine, RX is hydrogen or C-C-alkyl; R, -C2.-alkyl, or their Cll salts; Known compounds have properties to reduce or weaken the elevated pressure associated with the use of antihypertensive drugs, in particular, anti-hypertensive. Method for preparing compounds FO1 "uly (I) based on the known reaction. interaction of acid chlorides of acids with the corresponding acids in an inert organic solvent. in width The temperature range of the process (from low temperatures Jao exceeding). The purpose of the invention is to expand the range of tools that affect a living organism.
    Or their salts B 3 dH-dOOH where RJI% have the indicated meanings, is reacted with an amino acid form. For H H-CH-COOH, where R has the indicated meanings, the process is carried out in an aqueous solution of sodium carbonate with a subsequent target release. product in free eide or in salt form. PRI me R i. (3-acetylthio-2-methylpropanoyl) -L-arginine. L-aREININ (2.61 g) was dissolved in a mixture of sodium carbonate (3.2 g) and water (30 ml) and the solution was cooled in an ice bath. 3-Acetylthio-2-methylpropanoyl chloride (2.7 g) is added and the reaction mixture is stirred at room temperature for 1.5 hours. 50 ml of ion-exchange SMO are added. PY (AG 50W) and the suspension is loaded into a column with the same resin (BO ml).
    权利要求:
    Claims (1)
    [1]
    Claim
    The method of obtaining mercaptoacylamino acids of the General formula 1. · "1 tHi-tiH-CO-NR-dH-COOH
    6de is hydrogen; C4-C j-alkyl substituted with phenyl, hydroxyphenyl, indole or guanidine; R1. - hydrogen or C4-C g- alkyl, R5-C4-C ^ -alkyl, or their salts, consisting in those that the thio acid chloride of the formula. e e <* o- $ - · Cu-ito. 'where 8¾ have the indicated values, are reacted with an amino acid of the formula where 84 has the indicated values, and the process is carried out in an aqueous solution of sodium carbonate, followed by isolation of the target product in free form or in the form of a salt.
    类似技术:
    公开号 | 公开日 | 专利标题
    SU955857A3|1982-08-30|Process for producing mercaptoacylamino acids or their salts
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    SU648103A3|1979-02-15|Method of obtaining tetrazol |-quinolines or salts thereof
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    US2858309A|1958-10-28|New aminobenzene sulfonamide
    US4259525A|1981-03-31|Methionine process
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    US3090785A|1963-05-21|New process for preparing acylated
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    US2970148A|1961-01-31|1-isonicotinyl-2-veratrylidene hydrazine
    KR800001550B1|1980-12-27|Preparing process for 5-|hydantoins
    SU514825A1|1976-05-25|Method for preparing 1-phenyl-1-cyclohexyl-3- | -propanol-1 hydrochloride
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    同族专利:
    公开号 | 公开日
    DE2717548A1|1977-12-01|
    AU2410677A|1978-10-12|
    NO771623L|1977-11-11|
    PL197963A1|1978-03-28|
    GB1577415A|1980-10-22|
    FR2372624B1|1980-05-09|
    SU697049A3|1979-11-05|
    CA1119177A|1982-03-02|
    CH621763A5|1981-02-27|
    FR2372624A1|1978-06-30|
    FR2367741A1|1978-05-12|
    BE854458A|1977-11-10|
    PL106032B1|1979-11-30|
    AU513622B2|1980-12-11|
    HU177750B|1981-12-28|
    CH620202A5|1980-11-14|
    JPS6120544B2|1986-05-22|
    PL107991B1|1980-03-31|
    SE7705382L|1977-11-11|
    ZA772256B|1978-03-29|
    US4112119A|1978-09-05|
    YU116877A|1982-08-31|
    CS204001B2|1981-03-31|
    IE44821B1|1982-04-07|
    SU818479A3|1981-03-30|
    US4053651A|1977-10-11|
    DD130477A5|1978-04-05|
    FR2367741B1|1982-10-29|
    NL7704712A|1977-11-14|
    DE2717548C2|1990-05-03|
    DK203177A|1977-11-11|
    IE44821L|1977-11-10|
    JPS52136117A|1977-11-14|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US05/684,606|US4053651A|1976-05-10|1976-05-10|Compounds and method for alleviating angiotensin related hypertension|
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